What does the science actually say about food, metabolism, and the brain-body connection? A working scientist reads the peer-reviewed literature — so you get the real story, not the headlines.
For the first time, researchers can identify which specific lipids bind to specific proteins inside living cells. Lipid-trap mass spectrometry (LTMS) opens a new chapter in understanding disease — and a new field: functional lipid-protein interactomics.
Read articleInhibiting 15-PGDH restores PGE₂ in arthritic joints — regenerating cartilage and reducing pain. The lipid signaling story behind a potential first disease-modifying treatment for osteoarthritis.
The 2025–2030 guidelines rehabilitated butter and beef tallow while keeping the 10% saturated fat limit. A lipid scientist reads the fine print — where the nuance is justified, and where it isn't.
Atomic-scale simulations revealed membrane lipids interact with the most drugged protein family through previously unknown backdoor pathways — opening new avenues for drug discovery.
PPAR agonists delivered via lipid nanoparticle to adipose macrophages reversed obesity and insulin resistance in three rodent models within weeks.
A 2025 review of 18 studies found the Mediterranean diet showed the most consistent cognitive benefits of any dietary pattern. A lipid scientist explains the molecular mechanisms.
A mass spectrometer detects thousands of molecules in a single drop of blood. How it works — and why it's becoming one of the most powerful tools in medicine.
The Mediterranean diet is the most scientifically validated dietary pattern in human history. I grew up eating it in Campania — the region that gave the world mozzarella, ragù, and pizza. These posts pair traditional Southern Italian recipes with the peer-reviewed science behind why they work.
One pot. Six ingredients. Twenty minutes. OEA satiety signaling, resistant starch, odd-chain fatty acids from Pecorino — and my family's recipe.
Resistant starch, bioavailable lycopene, brain-crossing antioxidants, complete plant protein — all in one bowl, under 30 minutes, for five dollars.
Colatura di alici — the amber liquid from salted anchovies in Cetara — is one of the most concentrated sources of EPA and DHA in the Mediterranean diet. Fermentation science, omega-3 biochemistry, and the recipe.
The only nut with significant omega-3 content — plus ellagitannins converted by gut bacteria to urolithins, dietary melatonin, and a polyphenol profile that rivals berries. The science, with a Campanian walnut pasta sauce.
Every time you eat olive oil, your gut releases oleoylethanolamide. Here's what 20 years of research — including work from my own lab — reveals about how this tiny molecule controls hunger.
The DHA in your brain is largely made by your liver. When that process breaks down — as in Alzheimer's disease — the brain feels it. The liver-brain lipid axis explained.
Anandamide — your brain's natural cannabis-like compound — is significantly reduced in Alzheimer's disease. Here's what that means and where the research is heading.